Follicular lymphoma (FL) is a form of non-Hodgkin’s Lymphoma (NHL), a blood cancer that involves white blood cells.
White blood cells help fight infections. However, unhealthy white blood cells can build up in the lymph nodes, bone marrow, and spleen (see picture).
FL can be a life-long disease. FL is the most common type of slow-growing NHL.
What does third-line or later (3L+) follicular lymphoma mean?
3L+ FL means that after at least 2 prior treatments, your FL has relapsed (returned) or is refractory (has not responded to treatment).
Understanding FL that has returned or has not responded to treatment
When your FL has not responded or has returned following 2 treatments, symptoms may be similar to ones you have experienced before, but this can vary from patient to patient.
Symptoms of FL may be seen in other conditions as well. Only your doctor will be able to tell if your symptoms are related to FL.
This may include routine tests, such as physical exams, blood cell counts, and bone marrow biopsies to identify the sources of symptoms.
There is no cure for FL. However, based on your experience with FL, you may have different treatment goals, such as:
If your doctor has concluded that your FL is relapsed or refractory to at least 2 prior treatments, you may be a candidate for an innovative option: bispecific antibody treatment.
Antibody treatment is designed to find and destroy specific cells within the body. This therapy is an important part of FL treatment plans. It can also harm healthy cells in the body.
Bispecific antibodies are designed to target 2 different sites on different cells or the same cell. For example, a bispecific antibody binding to 2 different cells is thought to bring the cells together, such as an immune cell and a cancer cell. LUNSUMIO is designed to target and bind to CD3 proteins found on T cells and CD20 proteins found on FL cells and may bind to some healthy cells.
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